商品介绍
- Specification
- Product Description:
- Anti-HSD3B1 is intended for the semi-quantitative detection of Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta-And Steroid Delta-Isomerase 1 (HSD3B1) in paraffin sections.
- Immunogen:
- HSD3B1 (AAH31999.1, 1 a.a. ~373 a.a.) full length recombinant protein with GST tag.
- Host:
- Mouse
- Specificity:
- Human Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Note:
- Product image
- Protocol:
Protocol Download
- Regulation Status:
- USA:IVD Class 1(FDA Registered Establishment Number: 3007539499)Taiwan:產品名稱: 亞諾法免疫組織化學染色單株抗體 (未滅菌) (羥基-δ-5-類固醇脫氫酶-3β-和類固醇δ異構酶1單株抗體)許可證字號: 衛署醫器製壹字第004544號 (醫療器材管理辦法「免疫組織化學試劑與套組(B.1860)」第一等級鑒別範圍)
- Datasheet:
- Download
- Clone Name:
- Monoclonal antibody (3C11-D4)
- Publication Reference
- 1.
- Steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions.Azmahani A, Nakamura Y, Felizola SJ, Ozawa Y, Ise K, Inoue T, McNamara KM, Doi M, Okamura H, Zouboulis CC, Aiba S, Sasano H.J Steroid Biochem Mol Biol. 2014 Jul 29. pii: S0960-0760(14)00134-4. doi: 10.1016/j.jsbmb.2014.07.010.
- 2.
- Gestational Trophoblastic Tumors and Related Tumor-Like Lesions.Shih IM, Mazur MT, Kurman RJ.Blaustein"s Pathology of the Female Genital Tract 2011, 1075-1135, DOI: 10.1007/978 -1-4419-0489-8_20
- 3.
- Advances in the diagnosis of gestational trophoblastic tumors and tumor-like lesions.Mao TL, Shih IM.Expert Opin. Med. Diagn. (2009) 3(4):371-380
- 4.
- Chorangiocarcinoma: A Case Report and Review of the Literature.Ariel I, Boldes R, Weintraub A, Reinus C, Beller U, Arbel R.Int J Gynecol Pathol. 2009 May;28(3):267-71.
- 5.
- HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions.Mao TL, Kurman RJ, Jeng YM, Huang W, Shih IM.Am J Surg Pathol. 2008 Feb;32(2):236-42.
- 6.
- Trophogram, an immunohistochemistry-based algorithmic approach, in the differential diagnosis of trophoblastic tumors and tumorlike lesions.Shih IeM.Ann Diagn Pathol. 2007 Jun;11(3):228-34.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunoperoxidase of monoclonal antibody to HSD3B1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 0.02344 ug/ml]
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunohistochemical staining of various tissues with hematoxylin and HSD3B1 antibody under high magnification. [antibody concentration 3 ug/ml]( a ) Stomach( b ) Esophagus( c ) Endometrium( d ) Uterine cervix( e ) Placenta( f ) Ovary, clear cell carcinoma( g ) Hepatocellular carcinoma( h ) Breast cancer( i ) Colon adenocarcinoma ( j and k ) Cervical carcinoma( l, m, and n ) Choriocarcinoma( o ) Epithelioid trophoblastic tumor
- Protocol Download
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Gene Information
- Entrez GeneID:
- 3283
- Gene Name:
- HSD3B1
- Gene Alias:
- HSD3B,HSDB3,SDR11E1
- Gene Description:
- hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
- Omim ID:
- 109715
- Gene Ontology:
- Hyperlink
- Other Designations:
- hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1,short chain dehydrogenase/reductase family 11E, member 1
- Gene Pathway
- Androgen and estrogen metabolism
- C21-Steroid hormone metabolism
- Metabolic pathways
- Related Disease
- Adenocarcinoma
- Breast cancer
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Ductus Arteriosus, Patent
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Hypertension
- Hypertrophy, Left Ventricular
- Infant, Premature, Diseases
- Kidney Failure, Chronic
- Lung Neoplasms
- Lymphoma, Non-Hodgkin
- Neoplasms, Hormone-Dependent
- Obesity
- Obesity
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Abnova公司是专注于高通量蛋白表达和抗体制作，并将世界级的生物技术与台湾IT工业管理经验独特融于一体的全球性生物公司。Abnova通过基因组 学手段生产出的几万种重组蛋白和抗体，极大的扩展了生物试剂应用的视野和多样性。同时，Abnova还在不断的扩展其在系统应用中的产品线，包括成对抗 体、ELISA试剂盒、原位杂交荧光探针、无表达蛋白定量以及可用于蛋白翻译研究、诊断和制药公司应用的基础型体外诊断设备等。作为Abnova的授权代理商，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为中国区域客户提供Abnova优质的产品和技术服务。
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