商品介绍
- Specification
- Product Description:
- TP53 (phospho S46) (Human) ELISA Kit is designed to detect and quantify the level of human p53 protein that is phosphorylated at serine residue 46. Since the amino acid sequence surrounding serine 46 is not conserved in mouse and rat p53, this ELISA kit can not be used for mouse and rat cells. This assay is intended for the detection of phosphorylated human p53 at serine 46 from cell lysate.
- Calibration Range:
- 1.56 to 100 U/mL
- Limit of Detection:
- 1.450 U/mL
- Reactivity:
- Human
- Quality Control Testing:
- Standard curveThe standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
- Storage Instruction:
- Store the kit at 4°C.
- Protocol:
- Please click to inquiry
- Suitable Sample:
- Cell Lysate
- Sample Volume:
- 100 uL
- Label:
- HRP-conjugate
- Detection Method:
- Colorimetric
- Regulation Status:
- For research use only (RUO)
- Datasheet:
Download
- Publication Reference
- 1.
- High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.Pauloin T, Dutot M, Joly F, Warnet JM, Rat P.Mol Vis. 2009;15:577-83. Epub 2009 Mar 23.
- Applications
- Quantification
- Application Image
- Quantification
- Gene Information
- Entrez GeneID:
- 7157
- Gene Name:
- TP53
- Gene Alias:
- FLJ92943,LFS1,TRP53,p53
- Gene Description:
- tumor protein p53
- Omim ID:
- 114480, 114500, 114550, 151623, 161550, 191170, 202300, 260350
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it"s believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq
- Other Designations:
- p53 antigen,p53 transformation suppressor,p53 tumor suppressor,phosphoprotein p53,transformation-related protein 53
- Interactome
- Gene Pathway
- Amyotrophic lateral sclerosis (ALS)
- Apoptosis
- Basal cell carcinoma
- Bladder cancer
- Cell cycle
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- Glioma
- Huntington"s disease
- MAPK signaling pathway
- Melanoma
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- p53 signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Thyroid cancer
- Wnt signaling pathway
- Related Disease
- Abortion, Habitual
- Abortion, Spontaneous
- Acquired Hyperostosis Syndrome
- Acute Disease
- Adenocarcinoma
- Adenocarcinoma, Clear Cell
- Adenocarcinoma, Follicular
- Adenocarcinoma, Mucinous
- Adenoma
- Adenoma, Liver Cell
- Adenomatous Polyposis Coli
- Adrenal Cortex Neoplasms
- Albuminuria
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Ameloblastoma
- Aneuploidy
- Anoxia
品牌介绍
Abnova公司是专注于高通量蛋白表达和抗体制作，并将世界级的生物技术与台湾IT工业管理经验独特融于一体的全球性生物公司。Abnova通过基因组 学手段生产出的几万种重组蛋白和抗体，极大的扩展了生物试剂应用的视野和多样性。同时，Abnova还在不断的扩展其在系统应用中的产品线，包括成对抗 体、ELISA试剂盒、原位杂交荧光探针、无表达蛋白定量以及可用于蛋白翻译研究、诊断和制药公司应用的基础型体外诊断设备等。作为Abnova的授权代理商，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为中国区域客户提供Abnova优质的产品和技术服务。
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