商品介绍
- Specification
- Product Description:
- Recombinant His-tagged human Fab fragment raised against c-Myc tag.
- Immunogen:
- Original antibody is raised against a synthetic peptide corresponding to amino acids 408-439 of human c-myc.
- Reactivity:
- Human
- Specificity:
- The epitope sequence, EQKLISEEDL, is located in aa 410-419 of human c-myc protein.
- Form:
- Liquid
- Purification:
- Immobilized Metal Affinity Chromatography
- Isotype:
- Human Fab fragment, His-tagged, kappa
- Recommend Usage:
- ImmunofluorescenceImmunohistochemistry (Frozen sections) (5 ug/mL)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)Immunoprecipitation (10 ug/mL)Western Blot (1 ug/mL)The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS, pH 7.2 (0.02% Proclin 300).
- Storage Instruction:
- Store at 4°C for up to 3 months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
- Antibody Species:
- Human
- Original clone:
- 9E10
- Datasheet:
Download
- Applications
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Immunofluorescence
- Immunoprecipitation
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Immunofluorescence
- Immunoprecipitation
- Gene Information
- Entrez GeneID:
- 4609
- Protein Accession#:
- P01106
- Gene Name:
- MYC
- Gene Alias:
- bHLHe39,c-Myc
- Gene Description:
- v-myc myelocytomatosis viral oncogene homolog (avian)
- Omim ID:
- 113970, 190080
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt"s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
- Other Designations:
- avian myelocytomatosis viral oncogene homolog,myc proto-oncogene protein,v-myc avian myelocytomatosis viral oncogene homolog
- Gene Pathway
- Acute myeloid leukemia
- Bladder cancer
- Cell cycle
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Jak-STAT signaling pathway
- MAPK signaling pathway
- Pathways in cancer
- Small cell lung cancer
- TGF-beta signaling pathway
- Thyroid cancer
- Wnt signaling pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Breast cancer
- Breast Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Chromosome Aberrations
- Colorectal Neoplasms
- Diabetes Complications
- Disease Progression
- Genetic Predisposition to Disease
- Helicobacter Infections
- Hematologic Diseases
- Hodgkin Disease
- Kidney Failure, Chronic
- Lung Neoplasms
- Lymphoma, B-Cell
- Lymphoma, B-Cell, Marginal Zone
品牌介绍
Abnova公司是专注于高通量蛋白表达和抗体制作，并将世界级的生物技术与台湾IT工业管理经验独特融于一体的全球性生物公司。Abnova通过基因组 学手段生产出的几万种重组蛋白和抗体，极大的扩展了生物试剂应用的视野和多样性。同时，Abnova还在不断的扩展其在系统应用中的产品线，包括成对抗 体、ELISA试剂盒、原位杂交荧光探针、无表达蛋白定量以及可用于蛋白翻译研究、诊断和制药公司应用的基础型体外诊断设备等。作为Abnova的授权代理商，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为中国区域客户提供Abnova优质的产品和技术服务。
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