商品介绍
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ALK.
- Immunogen:
- A synthetic peptide corresponding to amino acids 1570-1619 of human ALK.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 176
- Reactivity:
- Human
- Specificity:
- This antibody detects endogenous levels of total ALK protein.
- Form:
- Liquid
- Recommend Usage:
- ELISA (1:1000)Immunofluorescence (1:100~1:500)Immunohistochemistry (1:50~1:100)The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS ((without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
- Storage Instruction:
- Store at -20°C.Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Datasheet:
Download
- Publication Reference
- 1.
- The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling.Staber PB, Vesely P, Haq N, Ott RG, Funato K, Bambach I, Fuchs C, Schauer S, Linkesch W, Hrzenjak A, Dirks WG, Sexl V, Bergler H, Kadin ME, Sternberg DW, Kenner L, Hoefler G.Blood. 2007 Nov 1;110(9):3374-83. Epub 2007 Aug 9.
- 2.
- Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3.Kasprzycka M, Marzec M, Liu X, Zhang Q, Wasik MA.Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9964-9. Epub 2006 Jun 9.
- 3.
- Prognostic significance of CD56 expression for ALK-positive and ALK-negative anaplastic large-cell lymphoma of T/null cell phenotype.Suzuki R, Kagami Y, Takeuchi K, Kami M, Okamoto M, Ichinohasama R, Mori N, Kojima M, Yoshino T, Yamabe H, Shiota M, Mori S, Ogura M, Hamajima N, Seto M, Suchi T, Morishima Y, Nakamura S.Blood. 2000 Nov 1;96(9):2993-3000.
- 4.
- Lymphomas expressing ALK fusion protein(s) other than NPM-ALK.Falini B, Pulford K, Pucciarini A, Carbone A, De Wolf-Peeters C, Cordell J, Fizzotti M, Santucci A, Pelicci PG, Pileri S, Campo E, Ott G, Delsol G, Mason DY.Blood. 1999 Nov 15;94(10):3509-15.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry analysis of paraffin-embedded human brain tissue using ALK polyclonal antibody (Cat # PAB18081).Peptide "+" means "with peptide blocking".
- Immunohistochemistry
- Immunofluorescence
- Immunofluorescence analysis of HeLa cells, using ALK polyclonal antibody (Cat # PAB18081).Peptide "+" means "with peptide blocking".
- Enzyme-linked Immunoabsorbent Assay
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry
- Immunofluorescence
- enlarge
- Enzyme-linked Immunoabsorbent Assay
- Gene Information
- Entrez GeneID:
- 238
- Protein Accession#:
- Q9UM73
- Gene Name:
- ALK
- Gene Alias:
- CD246,Ki-1,TFG/ALK
- Gene Description:
- anaplastic lymphoma receptor tyrosine kinase
- Omim ID:
- 105590
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3" half of ALK, derived from chromosome 2, is fused to the 5" portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq
- Other Designations:
- ALK tyrosine kinase receptor,CD246 antigen,anaplastic lymphoma kinase (Ki-1),anaplastic lymphoma kinase Ki-1
- Related Disease
- Adenocarcinoma
- Carcinoma, Non-Small-Cell Lung
- Genetic Predisposition to Disease
- Kidney Failure, Chronic
- Lung Neoplasms
- Multiple Sclerosis
- Schizophrenia
- Schizophrenia
- Tobacco Use Disorder
品牌介绍
Abnova公司是专注于高通量蛋白表达和抗体制作，并将世界级的生物技术与台湾IT工业管理经验独特融于一体的全球性生物公司。Abnova通过基因组 学手段生产出的几万种重组蛋白和抗体，极大的扩展了生物试剂应用的视野和多样性。同时，Abnova还在不断的扩展其在系统应用中的产品线，包括成对抗 体、ELISA试剂盒、原位杂交荧光探针、无表达蛋白定量以及可用于蛋白翻译研究、诊断和制药公司应用的基础型体外诊断设备等。作为Abnova的授权代理商，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为中国区域客户提供Abnova优质的产品和技术服务。
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