商品介绍
- Specification
- Product Description:
- Mouse monoclonal antibody raised against human CD45RA.
- Immunogen:
- Fresh human lymph node lymphocytes depleted of surface immunoglobulin positive cells.
- Host:
- Mouse
- Theoretical MW (kDa):
- 220
- Reactivity:
- Human
- Form:
- Liquid
- Conjugation:
- APC
- Purification:
- Protein A/G purification
- Purity:
- >90%
- Isotype:
- IgG2b, kappa
- Recommend Usage:
- Flow Cytometry (20 uL/106 cells)ImmunofluorescenceImmunohistochemistry (Frozen sections)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS, pH 7.4 (protein stabilizer, 0.09% sodium azide).
- Storage Instruction:
- Store in the dark at 4°C.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Datasheet:
Download
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Immunofluorescence
- Flow Cytometry
- Flow cytometric analysis of human peripheral blood lymphocytes with CD45RA monoclonal antibody, clone HI100 (APC) (Cat # MAB13677).
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry (Frozen sections)
- Immunofluorescence
- Flow Cytometry
- enlarge
- Gene Information
- Entrez GeneID:
- 5788
- Protein Accession#:
- P08575
- Gene Name:
- PTPRC
- Gene Alias:
- B220,CD45,CD45R,GP180,LCA,LY5,T200
- Gene Description:
- protein tyrosine phosphatase, receptor type, C
- Omim ID:
- 126200, 151460, 609532
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
- Other Designations:
- CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide
- Gene Pathway
- Cell adhesion molecules (CAMs)
- Fc gamma R-mediated phagocytosis
- Primary immunodeficiency
- T cell receptor signaling pathway
- Related Disease
- Arthritis, Juvenile Rheumatoid
- Arthritis, Rheumatoid
- Ascariasis
- Autoimmune Diseases
- Cardiomyopathy, Dilated
- Diabetes Mellitus, Type 1
- Genetic Predisposition to Disease
- Graves Disease
- Hashimoto Disease
- Hepatitis B
- Hepatitis C
- Hepatitis, Autoimmune
- HIV Infections
- Inflammatory Bowel Diseases
- Lupus Erythematosus, Systemic
- Lymphopenia
- Multiple Sclerosis
- Paraparesis, Tropical Spastic
- Scleroderma, Systemic
品牌介绍
Abnova公司是专注于高通量蛋白表达和抗体制作，并将世界级的生物技术与台湾IT工业管理经验独特融于一体的全球性生物公司。Abnova通过基因组 学手段生产出的几万种重组蛋白和抗体，极大的扩展了生物试剂应用的视野和多样性。同时，Abnova还在不断的扩展其在系统应用中的产品线，包括成对抗 体、ELISA试剂盒、原位杂交荧光探针、无表达蛋白定量以及可用于蛋白翻译研究、诊断和制药公司应用的基础型体外诊断设备等。作为Abnova的授权代理商，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为中国区域客户提供Abnova优质的产品和技术服务。
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正规清关
CIF100%正规报关，提供发票
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限时必达 不达必赔
总部地址：
江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)
工作时间：周一至周五9:00~18:00
技术支持：
短信：18915418616
服务热线：
4000-520-616（全国）
☏ 0512-67156496（苏州）
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