商品介绍
- Specification
- Product Description:
- mutaFISH™ EML4wt ALKwt RNA Probes is designed to detect human EML4 and ALK gene rearrangement on single strand RNA in cells using padlock probe and in situ rolling-circle amplification technology.
- Supplied Product:
- Content:1. RT EML4 Primer2. RT ALK Primer3. mutaFISH™ EML4wt RNA Probe4. mutaFISH™ ALKwt RNA Probe5. Detection Probe-6-HEX6. Detection Probe-Texas Red X
- Storage Instruction:
- Store at -20°C.Aliquot to avoid repeated freezing and thawing.
- Note:
- We recommend mutaFISH™ RNA Accessory Kit (Catalog #: KA4915) which provides necessary reagents and enzymes for in situ reverse transcription, RNA digestion, mutaFISH™ hybridization, ligation and amplication prior to mutaFISH™.
- Protocol:
Protocol Download
- Technology:
- mutaFISH™ (mutation-specific Fluorescence In Situ Hybridization)
- Comparison:
- FISH Probes vs mutaFISH™ Probes
- Fluorophore:
- 6-HEX (Excitation Peak (nm): 533; Emission Peak (nm): 559)Texas Red X (Excitation Peak (nm): 595; Emission Peak613)
- Probe Position:
- Regulatory Status:
- For research use only (RUO)
- Video:
- Datasheet:
- Download
- Applications
- mutation specific, Fluorescence In Situ Hybridization (Cells)
- mutaFISH™ staining was performed in situ in human H1975 cells. EML4 was detected via purple signal (Texas Red); ALK was not detected.
- Application Image
- mutation specific, Fluorescence In Situ Hybridization (Cells)
- enlarge
- ALK
- EML4
- Gene Information
- Entrez GeneID:
- 238
- Gene Name:
- ALK
- Gene Alias:
- CD246,Ki-1,TFG/ALK
- Gene Description:
- anaplastic lymphoma receptor tyrosine kinase
- Omim ID:
- 105590
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3" half of ALK, derived from chromosome 2, is fused to the 5" portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq
- Other Designations:
- ALK tyrosine kinase receptor,CD246 antigen,anaplastic lymphoma kinase (Ki-1),anaplastic lymphoma kinase Ki-1
- Gene Information
- Entrez GeneID:
- 27436
- Gene Name:
- EML4
- Gene Alias:
- C2orf2,DKFZp686P18118,ELP120,FLJ10942,FLJ32318,ROPP120
- Gene Description:
- echinoderm microtubule associated protein like 4
- Omim ID:
- 607442
- Gene Ontology:
- Hyperlink
- Other Designations:
- -
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