商品介绍
- Specification
- Product Description:
- FGFR2/CEN10 CISH Probe is designed for the qualitative detection of human FGFR2 gene amplifications as well as the detection of chromosome 10 alpha satellites in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
- Recommend Usage:
- The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18-25°C) and mix briefly before use.
- Supplied Product:
- Reagent Provided:This Probe is composed of:1. Digoxigenin-labeled polynucleotides, which target sequences mapping in 10q26.12-10q26.13* (chr10:123,080,085-123,492,398) harboring the FGFR2 gene region.2. Dinitrophenyl-labeled polynucleotides, which target sequences mapping in 10p11.1-q11.1 specific for the alpha satellite centromeric region D10Z1 of chromosome 10. 3. Formamide based hybridization buffer.*according to Human Genome Assembly GRCh37/hg19
- Storage Instruction:
- Store at 2-8°C in an upright position. Return to storage conditions immediately after use.
- Note:
- The probe is intended to be used in combination with the CISH Implementation Kit 2 (Catalog #: KA5366), which provides necessary reagents for specimen pretreatment and post-hybridization processing.Interpretation of results:Using the CISH Implementation Kit 2 (Cat # KA5366), hybridization signals of Digoxigenin-labeled polynucleotides appear as dark green colored distinct dots (FGFR2 gene region), and Dinitrophenyl-labeled polynucleotides appear as bright red colored distinct dots (CEN 10).Normal situation: In interphases of normal cells or cells without an amplification involving the FGFR2 gene region, two distinct dot-shaped green and two distinct dot-shaped red signals appear.Aberrant situation: In cells with an amplification of the FGFR2 gene region, an increased number of green signals or green signal clusters will be observed.Overlapping signals may appear as brown signals. Other signal patterns than those described above may be observed in some abnormal samples. These unexpected signal patterns should be further investigated.
- Probe Position:
- Regulatory Status:
- For research use only (RUO)
- Interpretation of Result:
- Datasheet:
Download
- Applications
- Chromogenic In Situ Hybridization (FFPE Tissue)
- Breast carcinoma tissue section with FGFR2 (green) amplification.
- Application Image
- Chromogenic In Situ Hybridization (FFPE Tissue)
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品牌介绍
Abnova公司是专注于高通量蛋白表达和抗体制作，并将世界级的生物技术与台湾IT工业管理经验独特融于一体的全球性生物公司。Abnova通过基因组 学手段生产出的几万种重组蛋白和抗体，极大的扩展了生物试剂应用的视野和多样性。同时，Abnova还在不断的扩展其在系统应用中的产品线，包括成对抗 体、ELISA试剂盒、原位杂交荧光探针、无表达蛋白定量以及可用于蛋白翻译研究、诊断和制药公司应用的基础型体外诊断设备等。作为Abnova的授权代理商，艾美捷科技有限公司凭借丰富的专业经验，将一如既往的为中国区域客户提供Abnova优质的产品和技术服务。
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